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Non-covalent interactions

Fold globally, bond locally

Nature Chemical Biology volume 6, pages 567–568 (2010)Cite this article

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Protein structures are considerably stabilized by local interactions. A new computational and structural analysis discovers that n→π* interactions between consecutive residues are stabilizing and ubiquitous in a variety of secondary structures.

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Figure 1: n→π* interactions between adjacent residues are local and restrict protein conformation.

References

  1. Pauling, L., Corey, R.B. & Branson, H.R. Proc. Natl. Acad. Sci. USA 37, 205–211 (1951).

    Article  CAS  Google Scholar 

  2. Bartlett, G.J., Choudhary, A., Raines, R.T. & Woolfson, D.N. Nat. Chem. Biol. 6, 615–620 (2010).

    Article  CAS  Google Scholar 

  3. Levinthal, C. Journal de chimie physique et de physico-chimie biologique 65, 44–45 (1968).

    Article  Google Scholar 

  4. Aurora, R., Creamer, T.P., Srinivasan, R. & Rose, G.D. J. Biol. Chem. 272, 1413–1416 (1997).

    Article  CAS  Google Scholar 

  5. Hinderaker, M.P. & Raines, R.T. Protein Sci. 12, 1188–1194 (2003).

    Article  CAS  Google Scholar 

  6. DeRider, M.L. et al. J. Am. Chem. Soc. 124, 2497–2505 (2002).

    Article  CAS  Google Scholar 

  7. Bretscher, L.E., Jenkins, C.L., Taylor, K.M., DeRider, M.L. & Raines, R.T. J. Am. Chem. Soc. 123, 777–778 (2001).

    Article  CAS  Google Scholar 

  8. Horng, J.C. & Raines, R.T. Protein Sci. 15, 74–83 (2006).

    Article  CAS  Google Scholar 

  9. Hodges, J.A. & Raines, R.T. Org. Lett. 8, 4695–4697 (2006).

    Article  CAS  Google Scholar 

  10. Gorske, B.C., Bastian, B.L., Geske, G.D. & Blackwell, H.E. J. Am. Chem. Soc. 129, 8928–8929 (2007).

    Article  CAS  Google Scholar 

Download references

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  1. Neal J. Zondlo is in the Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware, USA.,

    Neal J Zondlo

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  1. Neal J Zondlo
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Correspondence to Neal J Zondlo.

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The author declares no competing financial interests.

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Zondlo, N. Fold globally, bond locally. Nat Chem Biol 6, 567–568 (2010). https://doi.org/10.1038/nchembio.413

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