Because of the large number of phospholipids, their highly active metabolism and our lack of understanding of protein-lipid specificity, lipid signaling is a particularly challenging subject to study. Help might come from new tools that will allow us to follow and manipulate lipids and lipid-binding proteins in living cells.
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Schultz, C. Challenges in studying phospholipid signaling. Nat Chem Biol 6, 473–475 (2010). https://doi.org/10.1038/nchembio.389
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DOI: https://doi.org/10.1038/nchembio.389
