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Lipids

COX-2's new role in inflammation

COX-2 is the enzyme largely responsible for causing inflammation, a common mechanism of disease. A study now reports that derivatives generated by COX-2 from naturally occurring ω-3 fatty acids are anti-inflammatory mediators.

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Figure 1: COX-2-generated pro- and anti-inflammatory lipid mediators from ω-3 and ω-6 fatty acids.

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Correspondence to Chu Chen.

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The author declares no competing financial interests.

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Chen, C. COX-2's new role in inflammation. Nat Chem Biol 6, 401–402 (2010). https://doi.org/10.1038/nchembio.375

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