Drugs identified in high-content screens are often difficult to link to the cellular target, especially when multiple signaling pathways impinge on the phenotypic endpoint. A chemical-genetic approach in fruit fly cells now greatly improves the prioritization of drug hits by directing the screen toward a single pathway.
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Muellner, M., Nijman, S. Giving Rho(d) directions. Nat Chem Biol 6, 397–398 (2010). https://doi.org/10.1038/nchembio.373
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DOI: https://doi.org/10.1038/nchembio.373