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Stem cells

Metabolism regulates differentiation

Nature Chemical Biology volume 6, pages 176–177 (2010)Cite this article

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A reverse genetic engineering approach identifies metabolic enzymes and their cellular pathways as potential regulators of myoblast differentiation. Targeting these metabolic nodes has provocative implications for drug discovery and therapeutic efficacy.

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Figure 1: RNAi screens reveal that cell differentiation is regulated by key metabolic enzymes.

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Authors and Affiliations

  1. Timothy E. McGraw is in the Department of Biochemistry, New York, New York, USA.,

    Timothy E McGraw

  2. Vivek Mittal is in the Departments of Cardiothoracic Surgery and Cell and Developmental Biology, Weill Medical College of Cornell University, New York, New York, USA.,

    Vivek Mittal

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  1. Timothy E McGraw
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  2. Vivek Mittal
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Correspondence to Timothy E McGraw or Vivek Mittal.

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The authors declare no competing financial interests.

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McGraw, T., Mittal, V. Metabolism regulates differentiation. Nat Chem Biol 6, 176–177 (2010). https://doi.org/10.1038/nchembio.324

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