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Phenotypic screening

Fishing for neuroactive compounds

A high-throughput phenotypic screen in zebrafish embryos provides distinctive signatures by which neuroactive chemicals can be classified. These “behavioral barcodes” provide a systems approach to elucidating the mechanistic neuropharmacology of drugs and novel compounds.

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Figure 1: The complex polypharmacology of neuroactive compounds captured in biochemical and whole-animal assays.


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Correspondence to Jeremy L Jenkins.

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The authors declare no competing financial interests.

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Jenkins, J., Urban, L. Fishing for neuroactive compounds. Nat Chem Biol 6, 172–173 (2010).

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