Antibiotics can break down through the action of enzymes or through non-enzymatic processes. In the case of tetracycline, this drug 'debris' can have unexpected biological activities, including selection against resistance.
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Wright, G.D. Adv. Drug Deliv. Rev. 57, 1451–1470 (2005).
Yim, G., Wang, H.H. & Davies, J. Int. J. Med. Microbiol. 296, 163–170 (2006).
Palmer, A.C., Angelino, E. & Kishony, R. Nat. Chem. Biol. 6, 105–107 (2010).
Chopra, I. & Roberts, M. Microbiol. Mol. Biol. Rev. 65, 232–260 (2001).
Frimpter, G.W., Timpanelli, A.E., Eisenmenger, W.J., Stein, H.S. & Ehrlich, L.I. J. Am. Med. Assoc. 184, 111–113 (1963).
Thaker, M., Spanogiannopoulos, P. & Wright, G.D. Cell Mol. Life Sci. published online, doi:10.1007/s00018-009-0172-6 (28 October 2009).
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Wright, G. Inactive but not inert. Nat Chem Biol 6, 85–86 (2010). https://doi.org/10.1038/nchembio.299