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Synthetic biology

An RNP switch raises a roadblock

Nature Chemical Biology volume 6, pages 56 (2010) | Download Citation

Control of gene expression at the mRNA level is used extensively by cells. Now a biomimetic strategy yields a synthetic genetic switch in which an RNA-binding protein bound at the translation start site blocks progression of the ribosome.

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Author information

Affiliations

  1. Adrian R. Ferré-D'Amaré is at the Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.

    • Adrian R Ferré-D'Amaré

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Correspondence to Adrian R Ferré-D'Amaré.

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DOI

https://doi.org/10.1038/nchembio.287

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