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Protein folding: Sticky N17 speeds huntingtin pile-up

Nature Chemical Biology volume 6, pages 78 (2010) | Download Citation

Aggregation of huntingtin protein with an expanded polyglutamine region is enhanced by its 17-residue N-terminal domain, which binds to itself and to the polyglutamine region. This enhancement is inhibited when the N-terminal domain binds to the chaperonin TRiC.

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Author information

Affiliations

  1. Susan W. Liebman is in the Department of Biological Sciences at the University of Illinois at Chicago, Chicago, Illinois, USA.

    • Susan W Liebman
  2. Stephen C. Meredith is in the Department of Pathology and the Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois, USA.

    • Stephen C Meredith

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Corresponding authors

Correspondence to Susan W Liebman or Stephen C Meredith.

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DOI

https://doi.org/10.1038/nchembio.279

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