News & Views | Published:

Genomic variations on a CoA biosynthetic theme

Nature Chemical Biology volume 5, pages 871872 (2009) | Download Citation

A unique heterotrimeric assembly of individually inactive paralogs, two of which are also involved in regulating phosphatase activity, creates one of the key enzymes of coenzyme A biosynthesis in yeast, pointing to the possibility of a previously undescribed cross-talk between metabolic and signaling pathways.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    & Curr. Opin. Chem. Biol. 7, 238–251 (2003).

  2. 2.

    Mol. Biol. Evol. 21, 1242–1251 (2004).

  3. 3.

    et al. Nat. Chem. Biol. 5, 920–928 (2009).

  4. 4.

    , , & Bioinformatics 21 (suppl. 1), i478–i486 (2005).

  5. 5.

    , , & J. Biol. Chem. 284, 28137–28145 (2009).

  6. 6.

    , , , & J. Biol. Chem. 276, 13513–13516 (2001).

  7. 7.

    et al. J. Biol. Chem. 277, 21431–21439 (2002).

  8. 8.

    et al. Nat. Cell Biol. 11, 845–851 (2009).

  9. 9.

    et al. Nucleic Acids Res. 33, 5691–5702 (2005).

Download references

Author information

Affiliations

  1. Andrei L. Osterman is at the Burnham Institute for Medical Research, La Jolla, California, USA, and the Fellowship for Interpretation of Genomes, Burr Ridge, Illinois, USA.

    • Andrei L Osterman

Authors

  1. Search for Andrei L Osterman in:

Corresponding author

Correspondence to Andrei L Osterman.

About this article

Publication history

Published

DOI

https://doi.org/10.1038/nchembio.267

Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing