Early stages of protein evolution are inherently difficult to study. Genetic selection in Escherichia coli has now identified a life-sustaining de novo enzyme arising from a simple scaffold that is completely different from the native enzyme.
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Johansson, K., Winther, J. Hacking an enzyme. Nat Chem Biol 14, 202–204 (2018). https://doi.org/10.1038/nchembio.2574
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DOI: https://doi.org/10.1038/nchembio.2574
