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The ABCs of PTMs

Post-translational modifications (PTMs) are ubiquitous in all forms of life and often modulate critical protein functions. Recent chemical and biological advances have finally enabled scientists to precisely modify proteins at physiologically relevant positions, ushering in a new era of protein studies.

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Figure 1: Methods for synthesizing recombinant proteins containing PTMs.
Figure 2: Basic applications of modified recombinant proteins.
Figure 3: The future of PTM studies.


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K.W.B. acknowledges support from the NSF (DGE-1122492), and J.R. is supported by the NIH (R01GM125951; R01GM117230; P01DK017433; U54CA209992).

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Correspondence to Jesse Rinehart.

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Barber, K., Rinehart, J. The ABCs of PTMs. Nat Chem Biol 14, 188–192 (2018).

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