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GPCR

Lock and key become flexible

Nature Chemical Biology volume 14, pages 201202 (2018) | Download Citation

G-protein-coupled receptors (GPCRs) are critically involved in signal transduction. Structural views of several GPCRs have recently been obtained, but the structural principles determining subtype selectivity are still mostly elusive. Now, a combined solid-state NMR and molecular-modeling approach reveals how bradykinin GPCRs distinguish between closely related peptide ligands.

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Author information

Affiliations

  1. Marc Baldus is in the NMR group of the Bijvoet Center for Biomolecular Research, Utrecht University, Utrecht, The Netherlands.

    • Marc Baldus

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Competing interests

The author declares no competing financial interests.

Corresponding author

Correspondence to Marc Baldus.

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DOI

https://doi.org/10.1038/nchembio.2567

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