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GPCR

Lock and key become flexible

Nature Chemical Biology volume 14, pages 201–202 (2018)Cite this article

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G-protein-coupled receptors (GPCRs) are critically involved in signal transduction. Structural views of several GPCRs have recently been obtained, but the structural principles determining subtype selectivity are still mostly elusive. Now, a combined solid-state NMR and molecular-modeling approach reveals how bradykinin GPCRs distinguish between closely related peptide ligands.

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Figure 1: Novel insight into subtype selectivity of bradykinin GPCRs.

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Authors and Affiliations

  1. NMR group of the Bijvoet Center for Biomolecular Research, Utrecht University, Utrecht, The Netherlands

    Marc Baldus

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  1. Marc Baldus
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Correspondence to Marc Baldus.

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The author declares no competing financial interests.

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Baldus, M. Lock and key become flexible. Nat Chem Biol 14, 201–202 (2018). https://doi.org/10.1038/nchembio.2567

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