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Drug development

Allosteric inhibitors hit USP7 hard

A potent and specific small-molecule inhibitor of a long-sought-after anticancer drug target, USP7, that acts allosterically to inhibit MDM2-stabilizing activity foretells of more allosteric inhibitors for deubiquitinases and E3 ligases.

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Figure 1: Screening cascades to identify small-molecule-and protein-based deubiquitinase inhibitors.


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Correspondence to Sachdev S Sidhu.

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Zhang, W., Sidhu, S. Allosteric inhibitors hit USP7 hard. Nat Chem Biol 14, 110–111 (2018).

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