News & Views | Published:

Drug development

Allosteric inhibitors hit USP7 hard

Nature Chemical Biology volume 14, pages 110111 (2018) | Download Citation

A potent and specific small-molecule inhibitor of a long-sought-after anticancer drug target, USP7, that acts allosterically to inhibit MDM2-stabilizing activity foretells of more allosteric inhibitors for deubiquitinases and E3 ligases.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    , , , & Nat. Rev. Drug Discov. 10, 29–46 (2011).

  2. 2.

    et al. Nat. Chem. Biol. 14, 118–125 (2018).

  3. 3.

    & J. Mol. Cell Biol. 9, 45–52 (2017).

  4. 4.

    et al. Cell Chem. Biol. (2017).

  5. 5.

    et al. Mol. Cancer Ther. 8, 2286–2295 (2009).

  6. 6.

    et al. J. Mol. Biol. 429, 3546–3560 (2017).

  7. 7.

    et al. Nature 550, 481–486 (2017).

  8. 8.

    et al. Nature 550, 534–538 (2017).

  9. 9.

    et al. Cell Chem. Biol. (2017).

  10. 10.

    et al. Science 339, 590–595 (2013).

  11. 11.

    et al. PLoS Pathog. 13, e1006372 (2017).

  12. 12.

    et al. Mol. Cell 62, 121–136 (2016).

  13. 13.

    et al. Mol. Cell 68, 456–470.e10 (2017).

Download references

Author information

Affiliations

  1. Wei Zhang and Sachdev S. Sidhu are in the Donnelly Centre for Cellular and Biomolecular Research, Banting and Best Department of Medical Research, and Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.

    • Wei Zhang
    •  & Sachdev S Sidhu

Authors

  1. Search for Wei Zhang in:

  2. Search for Sachdev S Sidhu in:

Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Sachdev S Sidhu.

About this article

Publication history

Published

DOI

https://doi.org/10.1038/nchembio.2557

Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing