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Drug development: Allosteric inhibitors hit USP7 hard

Nature Chemical Biology volume 14, pages 110111 (2018) | Download Citation

A potent and specific small-molecule inhibitor of a long-sought-after anticancer drug target, USP7, that acts allosterically to inhibit MDM2-stabilizing activity foretells of more allosteric inhibitors for deubiquitinases and E3 ligases.

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Author information

Affiliations

  1. Wei Zhang and Sachdev S. Sidhu are in the Donnelly Centre for Cellular and Biomolecular Research, Banting and Best Department of Medical Research, and Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.

    • Wei Zhang
    •  & Sachdev S Sidhu

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Sachdev S Sidhu.

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DOI

https://doi.org/10.1038/nchembio.2557

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