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Drug development: Allosteric inhibitors hit USP7 hard

A potent and specific small-molecule inhibitor of a long-sought-after anticancer drug target, USP7, that acts allosterically to inhibit MDM2-stabilizing activity foretells of more allosteric inhibitors for deubiquitinases and E3 ligases.

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Author information

Affiliations

  1. Wei Zhang and Sachdev S. Sidhu are in the Donnelly Centre for Cellular and Biomolecular Research, Banting and Best Department of Medical Research, and Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.

    • Wei Zhang
    •  & Sachdev S Sidhu

Authors

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Sachdev S Sidhu.