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Toward an orthogonal central dogma

The central dogma processes of DNA replication, transcription, and translation are responsible for the maintenance and expression of every gene in an organism. An orthogonal central dogma may insulate genetic programs from host regulation and allow expansion of the roles of these processes within the cell.

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Figure 1: The orthogonal central dogma concept.
Figure 2: Component orthogonal central dogma systems.


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We thank members of our group and reviewers for valuable comments. C.C.L. acknowledges the Defense Advanced Research Projects Agency (DARPA-14-49-AS-BRICS-FP-017), the National Institutes of Health (1DP2GM119163-01), and the Arnold and Mabel Beckman Foundation. M.C.J. acknowledges the Army Research Office (W911NF-16-1-0372), the National Science Foundation (MCB-1716766), the Air Force Research Laboratory Center of Excellence (FA8650-15-2-5518), the David and Lucile Packard Foundation, and the Camille-Dreyfus Teacher-Scholar Program. The US Government is authorized to reproduce and distribute reprints for Governmental purposes notwithstanding any copyright notation thereon. The views and conclusions contained herein are those of the authors and should not be interpreted as necessarily representing the official policies or endorsements, either expressed or implied, of Air Force Research Laboratory or the US Government. J.W.C. acknowledges the Medical Research Council, UK (MC_U105181009 and MC_UP_A024_1008) and the European Research Council (ERC Advanced Grant (SGCR)). C.A.V. acknowledges the Office of Naval Research Multidisciplinary University Research Initiative (N00014-16-1-2388).

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Correspondence to Chang C Liu, Michael C Jewett, Jason W Chin or Chris A Voigt.

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The authors declare no competing financial interests.

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Liu, C., Jewett, M., Chin, J. et al. Toward an orthogonal central dogma. Nat Chem Biol 14, 103–106 (2018).

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