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Notch signaling

A sweet strategy

Nature Chemical Biology volume 14, pages 34 (2018) | Download Citation

Glycosylation of Notch receptors regulates ligand-induced Notch signaling, which is essential for normal development in animals. Fucose analogs targeting Notch glycosylation serve as ligand-specific Notch inhibitors and facilitate the understanding of how O-glycan regulates Notch–ligand interactions.

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Author information

Affiliations

  1. Tetsuya Okajima is at the Department of Biochemistry II, Nagoya University Graduate School of Medicine, Nagoya, Japan.

    • Tetsuya Okajima

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Competing interests

The author declares no competing financial interests.

Corresponding author

Correspondence to Tetsuya Okajima.

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DOI

https://doi.org/10.1038/nchembio.2532

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