Glycosylation of Notch receptors regulates ligand-induced Notch signaling, which is essential for normal development in animals. Fucose analogs targeting Notch glycosylation serve as ligand-specific Notch inhibitors and facilitate the understanding of how O-glycan regulates Notch–ligand interactions.
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Okajima, T. A sweet strategy. Nat Chem Biol 14, 3–4 (2018). https://doi.org/10.1038/nchembio.2532
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DOI: https://doi.org/10.1038/nchembio.2532
