The 'off-targets' of a drug are often poorly characterized yet could be harnessed in the treatment of complex diseases. A recent study used a small-molecule screening in non-small-cell lung cancer to repurpose an FDA-approved ALK/IGF1R inhibitor and uncover its mechanism of action.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
A pH-Induced Reversible Assembly System with Resveratrol-Controllable Loading and Release for Enhanced Tumor-Targeting Chemotherapy
Nanoscale Research Letters Open Access 06 September 2019
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
References
Hu, Q., Sun, W., Wang, C. & Gu, Z. Adv. Drug Deliv. Rev. 98, 19–34 (2016).
Chabner, B. A. & Roberts, T.G. Jr. Nat. Rev. Cancer 5, 65–72 (2005).
Leeson, P.D. & Springthorpe, B. Nat. Rev. Drug Discov. 6, 881–890 (2007).
Hopkins, A.L. Nat. Chem. Biol. 4, 682–690 (2008).
Kuenzi, B.M. et al. Nat. Chem. Biol. 13, 1222–1231 (2017).
Dang, C.V., Reddy, E.P., Shokat, K.M. & Soucek, L. Nat. Rev. Cancer 17, 502–508 (2017).
Vogelstein, B. & Kinzler, K.W. Trends Genet. 9, 138–141 (1993).
Robin, X. et al. Clin. Pharmacol. Ther. 94, 646–650 (2013).
Lovly, C.M. et al. Nat. Med. 20, 1027–1034 (2014).
Tan, D.S.W. et al. J. Thorac. Oncol. 11, 1550–1557 (2016).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Saginc, G., Voellmy, F. & Linding, R. Harnessing off-target effects. Nat Chem Biol 13, 1204–1205 (2017). https://doi.org/10.1038/nchembio.2519
Published:
Issue Date:
DOI: https://doi.org/10.1038/nchembio.2519
This article is cited by
-
A pH-Induced Reversible Assembly System with Resveratrol-Controllable Loading and Release for Enhanced Tumor-Targeting Chemotherapy
Nanoscale Research Letters (2019)