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Genome mining

Digging the tunnel for chemical space

Nature Chemical Biology volume 13, pages 10611062 (2017) | Download Citation

Genome mining reveals a new ribosomally synthesized and post-translationally modified peptide (RiPP) from Klebsiella pneumoniae. This new antibiotic inhibits bacterial ribosomes by obstructing the peptide exit tunnel, and its modular nature presents a unique opportunity for future engineering of antibacterial drugs.

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Author information

Affiliations

  1. Ha An Nguyen is in the Department of Chemistry, Emory University, Atlanta, Georgia, USA.

    • Ha An Nguyen
  2. Christine M. Dunham is in the Emory Antibiotic Resistance Center and the Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia, USA.

    • Christine M Dunham

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Christine M Dunham.

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DOI

https://doi.org/10.1038/nchembio.2480

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