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Genome mining

Digging the tunnel for chemical space

Nature Chemical Biology volume 13, pages 1061–1062 (2017)Cite this article

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Genome mining reveals a new ribosomally synthesized and post-translationally modified peptide (RiPP) from Klebsiella pneumoniae. This new antibiotic inhibits bacterial ribosomes by obstructing the peptide exit tunnel, and its modular nature presents a unique opportunity for future engineering of antibacterial drugs.

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Figure 1: Klebsazolicin (KLB) blocks the peptide exit tunnel of the ribosome.

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Authors and Affiliations

  1. Department of Chemistry, Emory University, Atlanta, Georgia, USA

    Ha An Nguyen

  2. Emory Antibiotic Resistance Center and the Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia, USA

    Christine M Dunham

Authors
  1. Ha An Nguyen
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  2. Christine M Dunham
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Correspondence to Christine M Dunham.

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The authors declare no competing financial interests.

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Nguyen, H., Dunham, C. Digging the tunnel for chemical space. Nat Chem Biol 13, 1061–1062 (2017). https://doi.org/10.1038/nchembio.2480

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