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Biosynthesis

SAM cycles up for colibactin

Nature Chemical Biology volume 13, pages 10591061 (2017) | Download Citation

The introduction of a cyclopropyl group is critical for imparting colibactin with the ability to cleave DNA. Nonribosomal peptide synthetase ClbH and polyketide synthase ClbI are now shown to work in concert to convert S-adenosylmethionine into this cyclopropyl group.

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Author information

Affiliations

  1. Steven G. Van Lanen is in the Department of Pharmaceutical Sciences, University of Kentucky, Lexington, Kentucky, USA.

    • Steven G Van Lanen

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The author declares no competing financial interests.

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Correspondence to Steven G Van Lanen.

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DOI

https://doi.org/10.1038/nchembio.2479

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