News & Views | Published:

Locking out viral replication

Nature Chemical Biology volume 5, pages 782783 (2009) | Download Citation

Subjects

Few antimicrobial drugs function by directly targeting RNA. A small molecule that binds the hepatitis C viral genome by 'locking' in a particular RNA conformation to inhibit viral protein production suggests a new paradigm for drug design.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    World Health Organization. Hepatitis C Fact Sheet No. 164 (WHO, Geneva, 1999).

  2. 2.

    et al. J. Med. Chem. 48, 7099–7102 (2005).

  3. 3.

    et al. Nat. Chem. Biol. 5, 823–825 (2009).

  4. 4.

    , , , & Genes Dev. 12, 67–83 (1998).

  5. 5.

    , & J. Am. Chem. Soc. 124, 9338–9339 (2002).

  6. 6.

    et al. Science 291, 1959–1962 (2001).

  7. 7.

    , , & Angew. Chem Int. Ed. Engl. 46, 226–229 (2007).

  8. 8.

    & Biochemistry 40, 7947–7956 (2001).

  9. 9.

    Nat. Struct. Biol. 7, 834–837 (2000).

  10. 10.

    & Annu. Rev. Microbiol. 59, 487–517 (2005).

  11. 11.

    , , & Nature 450, 1263–1267 (2007).

Download references

Author information

Affiliations

  1. Darren W. Begley is in the Department of Chemistry at the University of Washington, Seattle, Washington, USA.

    • Darren W Begley
  2. Gabriele Varani is in the Department of Chemistry and Department of Biochemistry at the University of Washington, Seattle, Washington, USA.

    • Gabriele Varani

Authors

  1. Search for Darren W Begley in:

  2. Search for Gabriele Varani in:

Corresponding author

Correspondence to Gabriele Varani.

About this article

Publication history

Published

DOI

https://doi.org/10.1038/nchembio.245

Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing