Few antimicrobial drugs function by directly targeting RNA. A small molecule that binds the hepatitis C viral genome by 'locking' in a particular RNA conformation to inhibit viral protein production suggests a new paradigm for drug design.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
References
World Health Organization. Hepatitis C Fact Sheet No. 164 (WHO, Geneva, 1999).
Seth, P.P. et al. J. Med. Chem. 48, 7099–7102 (2005).
Parsons, J. et al. Nat. Chem. Biol. 5, 823–825 (2009).
Pestova, T.V., Shatsky, I.N., Fletcher, S.P., Jackson, R.J. & Hellen, C.U. Genes Dev. 12, 67–83 (1998).
Kim, I., Lukavsky, P.J. & Puglisi, J.D. J. Am. Chem. Soc. 124, 9338–9339 (2002).
Spahn, C.M. et al. Science 291, 1959–1962 (2001).
Dibrov, S.M., Johnston-Cox, H., Weng, Y.H. & Hermann, T. Angew. Chem Int. Ed. Engl. 46, 226–229 (2007).
Leulliot, N. & Varani, G. Biochemistry 40, 7947–7956 (2001).
Williamson, J.R. Nat. Struct. Biol. 7, 834–837 (2000).
Winkler, W.C. & Breaker, R.R. Annu. Rev. Microbiol. 59, 487–517 (2005).
Zhang, Q., Stelzer, A.C., Fisher, C.K. & Al-Hashimi, H.M. Nature 450, 1263–1267 (2007).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Begley, D., Varani, G. Locking out viral replication. Nat Chem Biol 5, 782–783 (2009). https://doi.org/10.1038/nchembio.245
Issue Date:
DOI: https://doi.org/10.1038/nchembio.245