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Methylating mushrooms

The genome of the poisonous mushroom Omphalotus olearius provides a potent new biocatalytic strategy for installing backbone N-methyl amides on ribosomally synthesized peptides. This discovery could yield new biotechnologies for drug development from peptide macrocycles.

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Figure 1: Structure and origins of omphalotin A.


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Correspondence to Albert A Bowers.

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Bowers, A. Methylating mushrooms. Nat Chem Biol 13, 821–822 (2017).

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