The genome of the poisonous mushroom Omphalotus olearius provides a potent new biocatalytic strategy for installing backbone N-methyl amides on ribosomally synthesized peptides. This discovery could yield new biotechnologies for drug development from peptide macrocycles.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Chatterjee, J., Gilon, C., Hoffman, A. & Kessler, H. Acc. Chem. Res. 41, 1331–1342 (2008).
Bock, J.E., Gavenonis, J. & Kritzer, J.A. ACS Chem. Biol. 8, 488–499 (2013).
van der Velden, N.S. et al. Nat. Chem. Biol. 13, 833–835 (2017).
Walsh, C.T., O'Brien, R.V. & Khosla, C. Angew. Chem. Int. Ed. Engl. 52, 7098–7124 (2013).
Arnison, P.G. et al. Nat. Prod. Rep. 30, 108–160 (2013).
Sterner, O., Etzel, W., Mayer, A. & Anke, H. Nat. Prod. Lett. 10, 33–38 (1997).
Burkhart, B.J., Hudson, G.A., Dunbar, K.L. & Mitchell, D.A. Nat. Chem. Biol. 11, 564–570 (2015).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Bowers, A. Methylating mushrooms. Nat Chem Biol 13, 821–822 (2017). https://doi.org/10.1038/nchembio.2437
Published:
Issue Date:
DOI: https://doi.org/10.1038/nchembio.2437
