Commentary | Published:

Post-reductionist protein science, or putting Humpty Dumpty back together again

Nature Chemical Biology volume 5, pages 774777 (2009) | Download Citation

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In their native environments, proteins perform their biological roles in highly concentrated viscous solutions and in complex networks with numerous partners. Yet for many years, the normal practice has been to purify a protein of interest in order to characterize its structural and functional properties. In this Commentary, we discuss how protein scientists are now tackling the theoretical and methodological challenges of studying proteins in their physiological context.

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Author information

Affiliations

  1. Lila M. Gierasch is in the Department of Biochemistry and Molecular Biology and the Department of Chemistry, University of Massachusetts, Amherst, Amherst, Massachusetts, USA, and

    • Lila M Gierasch
  2. Anne Gershenson is in the Department of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, Amherst, Massachusetts, USA.

    • Anne Gershenson

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  1. Search for Lila M Gierasch in:

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Correspondence to Lila M Gierasch or Anne Gershenson.

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DOI

https://doi.org/10.1038/nchembio.241

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