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Protein degradation

DCAFinating splicing

Nature Chemical Biology volume 13, pages 575–576 (2017)Cite this article

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Chemical control of protein homeostasis and induction of protein destabilization are emerging therapeutic strategies. Two recent studies identify a set of sulfonamides that can modulate the CRL4DCAF15 E3 ligase complex to target the splicing factor RBM39 for proteasomal degradation.

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Figure 1: Chemical modulation of E3 ligase complexes.

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Authors and Affiliations

  1. Georg E. Winter is at the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.,

    Georg E Winter

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  1. Georg E Winter
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Correspondence to Georg E Winter.

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The author declares no competing financial interests.

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Winter, G. DCAFinating splicing. Nat Chem Biol 13, 575–576 (2017). https://doi.org/10.1038/nchembio.2378

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