Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Microbiology

A new language for small talk

A new signal–receptor pair involved in regulating biofilm formation and virulence was detected in Vibrio cholerae. Both the signal and the transcription factor belong to common classes of natural products and receptor proteins, suggesting widespread importance of related systems in nature.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1: DPO biosynthesis, function and possible interference by other pyrazines or pyrazinones in the gut.

Marina Corral Spence/Springer Nature

References

  1. Papenfort, K. et al. Nat. Chem. Biol. 13, 551–557 (2017).

    Article  CAS  Google Scholar 

  2. Schulz, S. & Dickschat, J.S. Nat. Prod. Rep. 24, 814–842 (2007).

    Article  CAS  Google Scholar 

  3. Henry, J.T. & Crosson, S. Annu. Rev. Microbiol. 65, 261–286 (2011).

    Article  CAS  Google Scholar 

  4. Papenfort, K. & Bassler, B.L. Nat. Rev. Drug Discov. 14, 576–588 (2016).

    CAS  Google Scholar 

  5. Hawver, L.A., Jung, S.A. & Ng, W.-L. FEMS Microbiol. Rev. 40, 738–752 (2016).

    Article  CAS  Google Scholar 

  6. Park, H.B. & Crawford, J.M. J. Antibiot. (Tokyo) 69, 616–621 (2016).

    Article  CAS  Google Scholar 

  7. Zimmermann, M. & Fischbach, M.A. Chem. Biol. 17, 925–930 (2010).

    Article  CAS  Google Scholar 

  8. MacDonald, J.C., Bishop, G.G. & Mazurek, M. Tetrahedron 32, 655–660 (1976).

    Article  Google Scholar 

  9. Jansen, R. et al. J. Nat. Prod. 77, 2545–2552 (2014).

    Article  CAS  Google Scholar 

  10. Millet, Y.A. et al. PLoS Pathog. 10, e1004405–e1004414 (2014).

    Article  Google Scholar 

  11. Hsiao, A. et al. Nature 515, 423–426 (2014).

    Article  CAS  Google Scholar 

  12. Guo, C.-J. et al. Cell 168, 517–526.e18 (2017).

    Article  CAS  Google Scholar 

  13. Zhou, L., Zhang, L.-H., Cámara, M. & He, Y.-W. Trends Microbiol. 25, 293–303 (2017).

    Article  CAS  Google Scholar 

  14. Brameyer, S., Bode, H.B. & Heermann, R. Trends Microbiol. 23, 521–523 (2015).

    Article  CAS  Google Scholar 

  15. Brameyer, S., Kresovic, D., Bode, H.B. & Heermann, R. Front. Cell. Infect. Microbiol. 4, 166 (2014).

    Article  Google Scholar 

  16. Zhou, Z. & Ma, S. ChemMedChem 12, 420–425 (2017).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Helge B Bode.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Shi, YM., Bode, H. A new language for small talk. Nat Chem Biol 13, 453–454 (2017). https://doi.org/10.1038/nchembio.2362

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nchembio.2362

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing