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Targeted protein degradation

You can glue it too!

Proteolysis-targeting chimera (PROTACs) are synthetic molecules that recruit neo-substrate proteins to a ubiquitin ligase for ubiquitination and subsequent degradation. Structural insight into the VHL–MZ1–BRD4 complex reveals how the rationally designed MZ1–PROTAC molecule mediates degradation of an unnatural protein substrate.

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Figure 1: Mechanism of neo-substrate degradation by bifunctional degraders.

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Correspondence to Nicolas H Thomä.

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Walczak, M., Petzold, G. & Thomä, N. You can glue it too!. Nat Chem Biol 13, 452–453 (2017). https://doi.org/10.1038/nchembio.2355

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