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Spatial regulation of axonal cAMP

In early-stage developing neurons, the cAMP–PKA (protein kinase A) signaling pathway is strongly inhibited. This negative control is later removed, unleashing cAMP–PKA signaling, particularly in distal axonal parts, thus allowing for axonal growth.

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Figure 1: Removal of an AKAP-dependent negative feedback on cAMP during development allows for the production of cAMP responses, with higher efficacy in distal axon.


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Correspondence to Pierre Vincent.

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Vincent, P., Castro, L. Spatial regulation of axonal cAMP. Nat Chem Biol 13, 348–349 (2017).

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