In early-stage developing neurons, the cAMP–PKA (protein kinase A) signaling pathway is strongly inhibited. This negative control is later removed, unleashing cAMP–PKA signaling, particularly in distal axonal parts, thus allowing for axonal growth.
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Vincent, P., Castro, L. Spatial regulation of axonal cAMP. Nat Chem Biol 13, 348–349 (2017). https://doi.org/10.1038/nchembio.2339