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Redox regulation

Taking AKTion on HNEs

Differential redox regulation of kinase isoforms serves to provide intricate control of cellular signaling events. In a new study, a single isoform of Akt, Akt3, is shown to be preferentially modified by lipid-derived electrophiles to modulate downstream signaling events in mammalian cells and zebrafish.

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Figure 1: Identifying the functional consequences of site-selective protein modification by HNE.


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Correspondence to Eranthie Weerapana.

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Weerapana, E. Taking AKTion on HNEs. Nat Chem Biol 13, 244–245 (2017).

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