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Host-pathogen interactions

Nucleotide circles of life and death

Nature Chemical Biology volume 13, pages 130–131 (2017)Cite this article

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A phosphodiesterase, CdnP, from Mycobacterium tuberculosis (M. tb.) helps the pathogen evade immune detection by degrading the second messenger cyclic di-AMP that alerts the host to its presence. Genetic knockout of CdnP dampens the virulence of the pathogen, suggesting that CdnP inhibitors are potential anti–M. tb. therapeutics.

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Figure 1: How the STING pathway detects Mycobacterium tuberculosis (M. tb.), and the pathogen's strategies to evade host innate immunity.

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Authors and Affiliations

  1. Lingyin Li is in the Department of Biochemistry, Stanford University, Stanford, California, USA., California, USA

    Lingyin Li

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  1. Lingyin Li
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Correspondence to Lingyin Li.

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The author declares no competing financial interests.

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Li, L. Nucleotide circles of life and death. Nat Chem Biol 13, 130–131 (2017). https://doi.org/10.1038/nchembio.2289

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