Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Natural products

Mapping an amazing thicket

The Global Natural Products Social Molecular Networking (GNPS) resource and the DEREPLICATOR algorithm provide new tools for analyzing mass spectral data and enabling natural products discovery.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Get just this article for as long as you need it


Prices may be subject to local taxes which are calculated during checkout

Figure 1: GNPS enables large MS/MS data sets to be shared and analyzed by users worldwide.


  1. Wang, M. et al. Nat. Biotechnol. 34, 828–837 (2016).

    Article  CAS  Google Scholar 

  2. Mohimani, H. et al. Nat. Chem. Biol. 13, 30–37 (2017).

    Article  CAS  Google Scholar 

  3. Krug, D. & Müller, R. Nat. Prod. Rep. 31, 768–783 (2014).

    Article  CAS  Google Scholar 

  4. Mohimani, H., Kim, S. & Pevzner, P.A. in Algorithms in Bioinformatics (eds. Raphael, B. & Tang, J.) 301–313 (Springer, Berlin, 2012).

    Book  Google Scholar 

  5. Guthals, A., Watrous, J.D., Dorrestein, P.C. & Bandeira, N. Mol. Biosyst. 8, 2535–2544 (2012).

    Article  CAS  Google Scholar 

  6. Kurita, K.L., Glassey, E. & Linington, R.G. Proc. Natl. Acad. Sci. USA 112, 11999–12004 (2015).

    Article  CAS  Google Scholar 

  7. Ng, J. et al. Nat. Methods 6, 596–599 (2009).

    Article  CAS  Google Scholar 

  8. Ibrahim, A. et al. Proc. Natl. Acad. Sci. USA 109, 19196–19201 (2012).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Christopher N Boddy.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Horsman, M., Boddy, C. Mapping an amazing thicket. Nat Chem Biol 13, 6–7 (2017).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing