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Stapled peptides

How to be quick on the uptake

Nature Chemical Biology volume 12, pages 764–765 (2016)Cite this article

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Stapled helices are promising compounds for inhibiting intracellular protein–protein interactions, but the discovery of peptides with the key property of cellular uptake has taken place largely through trial and error. A new study defines physicochemical parameters for designing hydrocarbon-stapled helices with a greater likelihood of cellular uptake.

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Figure 1: Cellular uptake and cell penetration of stapled helices.

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Authors and Affiliations

  1. Joshua Kritzer is at the Department of Chemistry, Tufts University, Medford, Massachusetts, USA.,

    Joshua A Kritzer

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  1. Joshua A Kritzer
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Correspondence to Joshua A Kritzer.

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The author declares no competing financial interests.

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Kritzer, J. How to be quick on the uptake. Nat Chem Biol 12, 764–765 (2016). https://doi.org/10.1038/nchembio.2183

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