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Target validation

Switching domains

Nature Chemical Biology volume 12, pages 659660 (2016) | Download Citation

Chemical probes and drugs often bind to functional domains on disease-relevant proteins. A study suggests a chemical genetic approach to establish on-target effects by swapping the targeted domain, affording resistance to pharmacological inhibition while retaining functionality.

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Author information

Affiliations

  1. Alessio Ciulli is at the School of Life Sciences, Division of Biological Chemistry and Drug Discovery, University of Dundee, Dundee, UK.

    • Alessio Ciulli

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Competing interests

The author declares no competing financial interests.

Corresponding author

Correspondence to Alessio Ciulli.

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DOI

https://doi.org/10.1038/nchembio.2154

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