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Chaperones

Speedy motion for function

Hsp90 is an energy-consuming molecular chaperone that activates oncogenic proteins in a complicated multi-step reaction. Photoinduced electron transfer (PET) quenching experiments with a fluorescent reporter have now identified molecular transitions at multiple timescales in the chaperone cycle of Hsp90.

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Figure 1: Cycling between open and closed states.

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Correspondence to Hagen Hofmann.

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Hofmann, H. Speedy motion for function. Nat Chem Biol 12, 576–577 (2016). https://doi.org/10.1038/nchembio.2130

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