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Drug discovery

Zebrafish uncover novel antipsychotics

Two independent high-throughput zebrafish behavioral screens of tens of thousands of compounds identify the 'finazines', a novel group of antipsychotics, and their endogenous genetic target, the σ1 receptor.

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Figure 1: Vertebrate pipeline for drug screening, genetic target validation, and future clinical trials.

Katie Vicari / Nature Publishing Group


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Correspondence to Philippe Mourrain.

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Leung, L., Mourrain, P. Zebrafish uncover novel antipsychotics. Nat Chem Biol 12, 468–469 (2016).

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