Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Drug discovery

Zebrafish uncover novel antipsychotics

Two independent high-throughput zebrafish behavioral screens of tens of thousands of compounds identify the 'finazines', a novel group of antipsychotics, and their endogenous genetic target, the σ1 receptor.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: Vertebrate pipeline for drug screening, genetic target validation, and future clinical trials.

Katie Vicari / Nature Publishing Group

References

  1. Hyman, S.E. Sci. Transl. Med. 4, 155cm11 (2012).

    Article  Google Scholar 

  2. Bruni, G. et al. Nat. Chem. Biol. 12, 559–566 (2016).

    Article  CAS  Google Scholar 

  3. Rennekamp, A.J. et al. Nat. Chem. Biol. 12, 552–558 (2016).

    Article  CAS  Google Scholar 

  4. Kalueff, A.V. et al. Zebrafish 10, 70–86 (2013).

    Article  Google Scholar 

  5. Martineau, P.R. & Mourrain, P. Methods 62, 292–303 (2013).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Philippe Mourrain.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Leung, L., Mourrain, P. Zebrafish uncover novel antipsychotics. Nat Chem Biol 12, 468–469 (2016). https://doi.org/10.1038/nchembio.2114

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nchembio.2114

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing