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Chemical genetics

Unraveling cell death mysteries

Non-apoptotic regulated cell death is not fully characterized, particularly for ferroptosis, the iron- and ROS-dependent form of regulated cell death. A systematic approach using modulatory profiling and cell line sensitivity analysis has unraveled the association of lipid metabolism with ferroptosis and enabled the discovery of a novel specific ferroptosis inducer.

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Figure 1: Induction of ferroptosis by FIN56.


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Correspondence to Evripidis Gavathiotis.

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Cotto-Rios, X., Gavathiotis, E. Unraveling cell death mysteries. Nat Chem Biol 12, 470–471 (2016).

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