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Chromatin targeting

A BET inhibitor workaround

A phenotypic cell-based screen identifies an inhibitor of BET bromodomain transcriptional activity via inhibition of the alternative bromodomain-containing protein TAF1.

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Figure 1: Modulation of BET bromodomain functional activity.


  1. Filippakopoulos, P. & Knapp, S. Nat. Rev. Drug Discov. 13, 337–356 (2014).

    Article  CAS  Google Scholar 

  2. Sdelci, S. et al. Nat. Chem. Biol. 12, 504–510 (2016).

    Article  CAS  Google Scholar 

  3. Lovén, J. et al. Cell 153, 320–334 (2013).

    Article  Google Scholar 

  4. Liu, X., Vorontchikhina, M., Wang, Y.L., Faiola, F. & Martinez, E. Mol. Cell. Biol. 28, 108–121 (2008).

    Article  Google Scholar 

  5. Li, H.-H., Li, A.G., Sheppard, H.M. & Liu, X. Mol. Cell 13, 867–878 (2004).

    Article  CAS  Google Scholar 

  6. Belkina, A.C. & Denis, G.V. Nat. Rev. Cancer 12, 465–477 (2012).

    Article  CAS  Google Scholar 

  7. Vidler, L.R., Brown, N., Knapp, S. & Hoelder, S. J. Med. Chem. 55, 7346–7359 (2012).

    Article  CAS  Google Scholar 

  8. Tran, T.A. et al. ACS Chem. Biol. 9, 2603–2611 (2014).

    Article  CAS  Google Scholar 

  9. Wang, L. et al. Nat. Commun. 4, 2035 (2013).

    Article  Google Scholar 

  10. Zengerle, M., Chan, K.H. & Ciulli, A. ACS Chem. Biol. 10, 1770–1777 (2015).

    Article  CAS  Google Scholar 

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Correspondence to Christopher J Burns.

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The author declares no competing financial interests.

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Burns, C. A BET inhibitor workaround. Nat Chem Biol 12, 469–470 (2016).

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