A phenotypic cell-based screen identifies an inhibitor of BET bromodomain transcriptional activity via inhibition of the alternative bromodomain-containing protein TAF1.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Filippakopoulos, P. & Knapp, S. Nat. Rev. Drug Discov. 13, 337–356 (2014).
Sdelci, S. et al. Nat. Chem. Biol. 12, 504–510 (2016).
Lovén, J. et al. Cell 153, 320–334 (2013).
Liu, X., Vorontchikhina, M., Wang, Y.L., Faiola, F. & Martinez, E. Mol. Cell. Biol. 28, 108–121 (2008).
Li, H.-H., Li, A.G., Sheppard, H.M. & Liu, X. Mol. Cell 13, 867–878 (2004).
Belkina, A.C. & Denis, G.V. Nat. Rev. Cancer 12, 465–477 (2012).
Vidler, L.R., Brown, N., Knapp, S. & Hoelder, S. J. Med. Chem. 55, 7346–7359 (2012).
Tran, T.A. et al. ACS Chem. Biol. 9, 2603–2611 (2014).
Wang, L. et al. Nat. Commun. 4, 2035 (2013).
Zengerle, M., Chan, K.H. & Ciulli, A. ACS Chem. Biol. 10, 1770–1777 (2015).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Burns, C. A BET inhibitor workaround. Nat Chem Biol 12, 469–470 (2016). https://doi.org/10.1038/nchembio.2107
Published:
Issue Date:
DOI: https://doi.org/10.1038/nchembio.2107
