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Optoepigenetics

An acetylation photoswitch

Histone 3 lysine 9 acetylation (H3K9ac) levels were modulated by photoresponsive histone deacetylase (HDAC) inhibitors to perturb the transcription of genes involved in cell cycle regulation and mitochondrial function.

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Figure 1: Gene regulation by light-induced HDAC inhibition.

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Correspondence to Christian A Olsen.

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Madsen, A., Olsen, C. An acetylation photoswitch. Nat Chem Biol 12, 306–307 (2016). https://doi.org/10.1038/nchembio.2049

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