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Translation

Ribosomes make sweeping arrests

The arrest peptides that function with the macrolide antibiotic erythromycin stall translating ribosomes in the presence of the antibiotic, leading to remodeling of the downstream mRNA and enhancement of the translation of resistance genes. Current work suggests that small changes in the nascent peptide dictate the ability of ribosomes to respond to this and other small molecules.

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Figure 1: Translational control mediated by arrest peptides and erythromycin.

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Correspondence to T Martin Schmeing.

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Alonzo, D., Schmeing, T. Ribosomes make sweeping arrests. Nat Chem Biol 12, 127–128 (2016). https://doi.org/10.1038/nchembio.2027

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