Protein aggregation is associated with more than 50 human pathologies, including prevalent conditions such as Alzheimer's and Parkinson's diseases. A phenotypic screen in Escherichia coli associating antibiotic resistance with the inhibition of protein aggregation now allows screening for chemical inhibitors of protein aggregation in a simple, fast and inexpensive manner.
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Schymkowitz, J., Rousseau, F. A rescue by chaperones. Nat Chem Biol 12, 58–59 (2016). https://doi.org/10.1038/nchembio.2006
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DOI: https://doi.org/10.1038/nchembio.2006
