Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Membrane curvature bends the laws of physics and chemistry

A 'chemical biology of cellular membranes' must capture the way that mesoscale perturbations tune the biochemical properties of constituent lipid and protein molecules and vice versa. Whereas the classical paradigm focuses on chemical composition, dynamic modulation of the physical shape or curvature of a membrane is emerging as a complementary and synergistic modus operandi for regulating cellular membrane biology.

This is a preview of subscription content

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: Lipid membranes.
Figure 2: Membrane composition and curvature contribute synergistically to the trafficking and sorting of membrane-associated proteins.
Figure 3: Separate motifs on the same protein could be envisaged to regulate its spatial organization and function independently in a curvature-dependent manner.

References

  1. 1

    Madsen, K.L., Bhatia, V.K., Gether, U. & Stamou, D. FEBS Lett. 584, 1848–1855 (2010).

    CAS  Article  Google Scholar 

  2. 2

    Baumgart, T., Capraro, B.R., Zhu, C. & Das, S.L. Annu. Rev. Phys. Chem. 62, 483–506 (2011).

    CAS  Article  Google Scholar 

  3. 3

    Bigay, J. & Antonny, B. Dev. Cell 23, 886–895 (2012).

    CAS  Article  Google Scholar 

  4. 4

    McMahon, H.T. & Boucrot, E. J. Cell Sci. 128, 1065–1070 (2015).

    CAS  Article  Google Scholar 

  5. 5

    Sprong, H., van der Sluijs, P. & van Meer, G. Nat. Rev. Mol. Cell Biol. 2, 504–513 (2001).

    CAS  Article  Google Scholar 

  6. 6

    Phillips, R., Ursell, T., Wiggins, P. & Sens, P. Nature 459, 379–385 (2009).

    CAS  Article  Google Scholar 

  7. 7

    Zimmerberg, J. & Kozlov, M.M. Nat. Rev. Mol. Cell Biol. 7, 9–19 (2006).

    CAS  Article  Google Scholar 

  8. 8

    Andersen, O.S. & Koeppe, R.E. Annu. Rev. Biophys. Biomol. Struct. 36, 107–130 (2007).

    CAS  Article  Google Scholar 

  9. 9

    daCosta, C.J.B., Dey, L., Therien, J.P.D. & Baenziger, J.E. Nat. Chem. Biol. 9, 701–707 (2013).

    CAS  Article  Google Scholar 

  10. 10

    Brown, M.F. Biochemistry 51, 9782–9795 (2012).

    CAS  Article  Google Scholar 

  11. 11

    Tonnesen, A., Christensen, S.M., Tkach, V. & Stamou, D. Biophys. J. 106, 201–209 (2014).

    CAS  Article  Google Scholar 

  12. 12

    Irannejad, R. et al. Nature 495, 534–538 (2013).

    CAS  Article  Google Scholar 

  13. 13

    Reynwar, B.J. et al. Nature 447, 461–464 (2007).

    CAS  Article  Google Scholar 

  14. 14

    Parton, D.L., Klingelhoefer, J.W. & Sansom, M.S. Biophys. J. 101, 691–699 (2011).

    CAS  Article  Google Scholar 

  15. 15

    Mukherjee, S. & Maxfield, F.R. Traffic 1, 203–211 (2000).

    CAS  Article  Google Scholar 

  16. 16

    Callan-Jones, A., Sorre, B. & Bassereau, P. Cold Spring Harb. Perspect. Biol. 3, a004648 (2011).

    Article  Google Scholar 

  17. 17

    Simons, K. & Gerl, M.J. Nat. Rev. Mol. Cell Biol. 11, 688–699 (2010).

    CAS  Article  Google Scholar 

  18. 18

    Weise, K., Triola, G., Brunsveld, L., Waldmann, H. & Winter, R. Biochemistry 131, 1557–1564 (2009).

    CAS  Google Scholar 

  19. 19

    Larsen, J.B. et al. Nat. Chem. Biol. 11, 192–194 (2015).

    CAS  Article  Google Scholar 

  20. 20

    Domanov, Y.A. et al. Proc. Natl. Acad. Sci. USA 108, 12605–12610 (2011).

    CAS  Article  Google Scholar 

  21. 21

    Lemmon, M.A. Nat. Rev. Mol. Cell Biol. 9, 99–111 (2008).

    CAS  Article  Google Scholar 

  22. 22

    Bigay, J., Gounon, P., Robineau, S. & Antonny, B. Nature 426, 563–566 (2003).

    CAS  Article  Google Scholar 

  23. 23

    Peter, B.J. et al. Science 303, 495–499 (2004).

    CAS  Article  Google Scholar 

  24. 24

    Hatzakis, N.S. et al. Nat. Chem. Biol. 5, 835–841 (2009).

    CAS  Article  Google Scholar 

  25. 25

    Campelo, F. & Kozlov, M.M. PLoS Comput. Biol. 10, e1003556 (2014).

    Article  Google Scholar 

  26. 26

    Demchenko, A.P., Mely, Y., Duportail, G. & Klymchenko, A.S. Biophys. J. 96, 3461–3470 (2009).

    CAS  Article  Google Scholar 

  27. 27

    Cui, H., Lyman, E. & Voth, G.A. Biophys. J. 100, 1271–1279 (2011).

    CAS  Article  Google Scholar 

  28. 28

    Vanni, S., Hirose, H., Barelli, H., Antonny, B. & Gautier, R. Nat. Commun. 5, 4916 (2014).

    CAS  Article  Google Scholar 

  29. 29

    Drin, G. et al. Nat. Struct. Mol. Biol. 14, 138–146 (2007).

    CAS  Article  Google Scholar 

  30. 30

    Reis, P., Holmberg, K., Watzke, H., Leser, M.E. & Miller, R. Adv. Colloid Interface Sci. 147–148, 237–250 (2009).

    Article  Google Scholar 

  31. 31

    Cajal, Y., Svendsen, A., Girona, V., Patkar, S.A. & Alsina, M.A. Biochemistry 39, 413–423 (2000).

    CAS  Article  Google Scholar 

  32. 32

    Ahyayauch, H., Villar, A.V., Alonso, A. & Goni, F.M. Biochemistry 44, 11592–11600 (2005).

    CAS  Article  Google Scholar 

  33. 33

    Groves, J.T. & Kuriyan, J. Nat. Struct. Mol. Biol. 17, 659–665 (2010).

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Dimitrios Stamou.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Iversen, L., Mathiasen, S., Larsen, J. et al. Membrane curvature bends the laws of physics and chemistry. Nat Chem Biol 11, 822–825 (2015). https://doi.org/10.1038/nchembio.1941

Download citation

Further reading

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing