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Chemical libraries

How dark is HTS dark matter?

Nature Chemical Biology volume 11, pages 904–905 (2015)Cite this article

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Selecting compounds for the chemical library is the foundation of high-throughput screening (HTS). After some years and multiple HTS campaigns, many molecules in the Novartis and NIH Molecular Libraries Program screening collections have never been found to be active. An in-depth exploration of the bioactivity of this 'dark matter' does in fact reveal some compounds of interest.

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Figure 1: A brief tale of the origin and fate of HTS libraries.

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  1. Ricardo Macarron is in the Department of Target Sciences, GlaxoSmithKline R&D, Collegeville, Pennsylvania, USA.,

    Ricardo Macarron

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  1. Ricardo Macarron
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Correspondence to Ricardo Macarron.

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The author declares no competing financial interests.

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Macarron, R. How dark is HTS dark matter?. Nat Chem Biol 11, 904–905 (2015). https://doi.org/10.1038/nchembio.1937

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