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Metabolism

Plugging the leak

Multiple mitochondrial components generate reactive oxygen species (ROS), but separating the consequences of each ROS-generating source from overall mitochondrial health is challenging. A new class of small-molecule inhibitors that selectively block ROS generation from one of the most active sources may provide a new approach toward achieving that goal.

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Figure 1: Schematic of function of S3QELs.

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Correspondence to Bryan C Dickinson.

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Dickinson, B. Plugging the leak. Nat Chem Biol 11, 831–832 (2015). https://doi.org/10.1038/nchembio.1934

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